February 11, 2014
Patricia LoRusso, D.O.
While some genes make us resistant to illness, others increase the risk of specific disease. That’s why cancer treatments are moving toward “personalized medicine” -- custom-tailored therapies based on individual gene structures. Personalized medicine focuses on physicians adjusting treatments to provide the best hope for response and outcome.
Patricia LoRusso, D.O., director of the Phase I Clinical Trials Program and professor of oncology at the Wayne State University School of Medicine, is conducting a Phase II clinical trial that explores the gene structures of patients with advanced stage melanoma -- the deadliest form of skin cancer. The study results could pave the way for improved melanoma treatment methods as well as developing a paradigm shift in how treatment decisions are made to treat cancer.
Melanoma kills more than 9,000 people each year, according to the American Cancer Society.
“There is a significant need for new treatment options for advanced-stage melanoma patients,” said Dr. LoRusso, who will co-lead the study with Jeffrey Trent, Ph.D. of the Translational Genomics Research Institute in Phoenix, Ariz. “During the study, we will do extensive genomic profiling of each patient’s blood and tumor. Using that data, we will create individual treatments using several new drugs as well as other conventional medications. It’s a very labor-intensive and complicated study. We’ll work with seven drug companies and 10 other cancer centers around the country.”
The Stand Up To Cancer® charitable program and the Melanoma Research Alliance are jointly funding this Phase II study, called the “Genomically Enabled Metastatic Melanoma Trials,” with additional assistance from the Gateway Foundation and additional sponsors. Drs. LoRusso and Trent are directing the SU2C/MRA Dream Team, comprised of a group of some of the nation’s leading cancer experts. The Barbara Ann Karmanos Cancer Institute and and TGen are the lead sites for the study, which began in January.
The trial will enroll approximately 100 patients nationally with metastatic melanoma who have failed immunotherapy and have certain molecular characterizations.
Dr. LoRusso said clinical trials are critical to providing new and better treatments for cancer patients.“If you have cancer, try to seek out a clinical trial,” she said. “Clinical trials are the only way to truly advance the science and treatment of cancer. We hope this study will pave the way for personalized medicine trials for other cancer types, not just melanoma.”