School of Medicine

Wayne State University School of Medicine
World AIDS Day Detroit Dec. 1 to feature Ryan White's mother, 'American Idol' contestants
In Headlines on November 26, 2014
World AIDS Day is Dec. 1.

World AIDS Day is Dec. 1.

World AIDS Day Detroit founder Phillip Kucab, Class of 2015.

World AIDS Day Detroit founder Phillip Kucab, Class of 2015.

World AIDS Day Detroit will take over the Detroit Opera House on Dec. 1 with three events: the annual Mayors Breakfast from 8 to 10 a.m.; a World AIDS Day Symposium from 11:30 a.m. to 1:30 p.m., which is free and open to the public; and a benefit concert at 7 p.m. featuring several popular contestants from various seasons of Fox television’s “American Idol.”

The Detroit Opera House is located at 1526 Broadway. Visit www.worldsaidsdaydetroit.com for event information and to purchase tickets.

World AIDS Day Detroit was launched in 2011 by Wayne State University School of Medicine fourth-year medical student Phillip Kucab to call greater attention to the disease, which is no longer a death sentence because of advancements in treatment but remains a viral concern, especially in Detroit.

“Together we can make a difference as Detroit commemorates World AIDS Day. HIV and AIDS is still a big problem and we need to be talking more openly about it. HIV is 100 percent preventable, yet we are still seeing 50,000 new infections each year,” Kucab said. “In the United States, one out of 200 people have HIV, but it’s three times that rate here in Detroit. One in four people with HIV do not even know they have it. Treatment and care is accessible, yet less than half of the people in and around Detroit who have HIV are being treated. We must do much better than that.”

Jeanne White-Ginder, mother of Ryan White, will speak at all events. Ryan, who was a hemophiliac, is remembered for his courageous fight to return to school after being expelled from his Kokomo, Ind., middle school because of the HIV infection he contracted through a contaminated blood transfusion. He became a national spokesperson for HIV/AIDS soon after, and his inspiring story garnered worldwide attention from many, including superstars Michael Jackson and Elton John, who remained by his side until his death in April 1990. Today, the Ryan White Care Act provides support, medical care and treatment to more than 500,000 people each year.

The annual Mayors Breakfast brings together Detroit-area mayors and community leaders, HIV/AIDS organizations and medical professionals in the fight against HIV. The breakfast will feature White-Ginder and a musical tribute to World AIDS Day. Tickets are available at www.worldaidsdaydetroit.com.

The symposium is open to the public and will include a presentation of the AIDS quilts, “The Ryan White Story” and performances from area schools on the main stage of the Detroit Opera House. Schools and students interested in participating or performing may call 313-757-1733 or email aburton@worldaidsdaydetroit.com.

World AIDS Day concludes with a 7 p.m. benefit concert starring six contestants from “American Idol.” They include Detroit natives and season 13 alumni Malaya Watson and Keri Lynn Roche, plus season two’s Kimberley Locke, season six’s Melinda Doolittle, season 13’s Ben Briley and Season 12’s Devin Velez. The concert will include a tribute to World AIDS Day and a special presentation of the AIDS quilts. General admission tickets are $20 and VIP tickets are $50. Tickets are available at www.ticketmaster.com and at the Detroit Opera House box office.

Dr. Hayley Thompson awarded $1.8 million to improve access to cancer survivor resources
In Headlines on November 24, 2014
Hayley Thompson, Ph.D.

Hayley Thompson, Ph.D.

Hayley Thompson, Ph. D., associate professor of oncology for the Wayne State University School of Medicine and of the Population Studies and Disparities Research Program at the Barbara Ann Karmanos Cancer Institute, was recently awarded a $1.8 million grant from the Agency for Healthcare Research and Quality.

The four-year grant, “eHealth Activity among African-American and White Cancer Survivors,” will study the use of Internet-based and mobile technologies by cancer survivors once their treatment has ended. The study will compare how African-American and caucasion cancer survivors access health resources electronically and the impact that has on their cancer survivorship.

Interviews will be conducted with a sample of approximately 1,230 African-American and white breast, prostate and colorectal cancer survivors from the metropolitan Detroit area to assess general eHealth activity, as well as specific eHealth activities, such as searching the Internet for health information, purchasing medication online or emailing a physician. There will also be a select sub-sample of 144 participants who will receive in-home visits from the study team to observe personal health information management in the home and examine the role of technology in the context of health information management. The results will guide the development of a prototype of a mobile application focused on cancer survivorship resources that can be accessed digitally.

“There are more than 14 million cancer survivors in the United States today. By 2024, this number is expected to increase to 19 million,” Dr. Thompson said. “While it is good news that more people are surviving cancer, many of these individuals face different health related issues. Working with eHealth technologies to help improve the cancer survivor’s access to needed services could help address and prevent some of the overwhelming needs and stresses that cancer survivors experience, as well as assist in the ever-changing health care arena. Having access to this technology also has the potential to help close the gap on health disparities.”

Objectives of the study include examining racial differences in general eHealth activity, examining racial differences in specific categories of eHealth activity, explore the role of eHealth in the broader context of personal health information management and using the data collected to develop a mobile application for cancer survivors.

The study will also compare cancer survivors who have Internet access against those without to better understand the factors that determine such access.

Dr. Thompson is the principal investigator on this study. Her team from the School of Medicine and KCI includes Deborah Charbonneau, Ph.D.; Tara Eaton, Ph.D.; Judith Abrams, Ph.D.; Jennifer Beebe-Dimmer, Ph.D.; Elisabeth Heath, M.D.; and Ke Zhang, Ph.D.

School of Medicine residents join medical students, Karmanos for Movember men's health fundraising
In Headlines on November 21, 2014
The Movember team Wayne State Flow Mo Bros are urology residents at the School of Medicine.

The Movember team Wayne State Flow Mo Bros are urology residents at the School of Medicine.

Things have gotten hairier at the Wayne State University School of Medicine lately.

The school's Department of Urology residents are taking on the school’s Department of Otolaryngology residents with their own respective Movember teams.

The urology residents call themselves the Flow Mo Bros and the otolaryngology residents have adopted the moniker Motor City Motolaryngology. Both are raising funds for Movember, a fundraising movement that asks everyone to raise money and awareness for prostate cancer and for men to shave their faces completely on Nov. 1 and then grow a moustache over the course of the month.

The Barbara Ann Karmanos Cancer Institute announced its own Movember team, the Karmanos Motown Warriors, this month. The School of Medicine’s medical students are also in mix, raising money for their team, WSUSOMoustaches, since late October. The Class of 2015’s Arjun Gowda and Umair Daimee organized this year’s White Coat Moustache Challenge.

WSU will compete against six other medical schools to see which can raise the most money for Movember. View real-time team challenge totals at http://monetwork.co/whitecoatchallenge.

“I worked on the oncology floor for a month during my third year. I saw cancer affect people, young and old, in ways that I could not imagine both physically and mentally. Words cannot describe what it’s like seeing someone my age being told that he has only a few more months to live,” Daimee said. “Words cannot describe what parents, sons, daughters and significant others go through knowing that their loved one will not be with them anymore. Although this cause concentrates on men's health, Movember is the least that I can do for all of them.”

Wayne State University and Karmanos are part of the True NTH initiative, funded by Movember. True NTH is a program that strives to improve the quality of life for men living with and beyond prostate cancer. Representing $36 million in investments, it unites more than 300 of the brightest prostate cancer researchers in the United States, Canada, Australia, New Zealand and the United Kingdom.

Several interventions for prostate cancer survivors and their caregivers are now under development by True NTH. Karmanos has nine members who are part of these development teams. Several of these initiatives are expected to be implemented at Karmanos and WSU within the next year.

“The reason we formed a team was because we were challenged by the (otolaryngology) doctors about who could raise more money,” said Co-Chief Urology Resident Dan Roeter, M.D., who is also the team captain. “I’m growing an awful moustache. When someone comes to me and says, ‘Your moustache looks awful,’ I can hand them a card promoting the cause.”

Dr. Roeter and his team have raised approximately $1,400. Dr. Roeter alone has raised $200 on his own Facebook page, along with an additional $410. At the end of the month, Dr. Roeter said, he’s going to raffle off his moustache to the nurse who donates the most to the Flow Mo Bros. That nurse will be able to shave off Dr. Roeter’s moustache as part of the bargain.

“Prostate cancer is a more prevalent disease, although Movember isn’t just about prostate cancer,” Dr. Roeter said. “It’s about men’s health. With being in urology, the cause is a perfect fit.”

For those who wish to make a donation, click on the following links:

Urology residents’ Flow Mo Bros, http://moteam.co/wayne-state-flow-mo-bros.

Karmanos Motown Warriors, http://moteam.co/karmanos-motown-warriors.

Otolaryngology residents’ Motor City Motolaryngology team, http://us.movember.com/team/1618073.

School of Medicine medical students’ WSUSOMoustaches team, http://us.movember.com/team/1613525.

Dr. Jack Sobel appointed interim dean of WSU School of Medicine
In Headlines on November 20, 2014
Jack Sobel, M.D.

Jack Sobel, M.D.

Wayne State University Provost and Senior Vice President for Academic Affairs Margaret Winters announced today that Professor Jack Sobel, M.D., chair of the WSU Department of Internal Medicine, is interim dean of the university’s School of Medicine.

Dr. Sobel, of West Bloomfield, Mich., begins his role as interim dean Nov. 24.

“Dr. Sobel is a very respected member of the faculty who has devoted his life to the treatment of patients and to medical research to improve therapies,” said Winters, who announced Dr. Sobel’s appointment Thursday. “He is the ideal person to lead the school during this transition period.”

Dr. Sobel replaces Dean Valerie M. Parisi, M.D., M.P.H., M.B.A., who in September announced her intention to leave the School of Medicine after five years as dean to accept a position at the University of South Florida. He will serve as interim dean while the university conducts a national search for a permanent dean.

“It is a privilege to be entrusted with leading our school of medicine, which plays such an integral role in the treatment and in medical research that improves the lives of so many, both in Michigan and around the world,” said Dr. Sobel, 72. “I am dedicated to continuing and strengthening that reputation with our outstanding faculty, and to providing the finest education for our medical and doctoral research students.”

Dr. Sobel is a longtime member of the School of Medicine faculty with extensive experience in both clinical practice and medical administration.

A 1965 graduate of the University of the Witwatersrand, Johannesburg in South Africa, he served as a research fellow in Infectious Diseases, Laboratory of Clinical Investigation, National Institute of Allergic and Infectious Diseases, with the National Institutes of Health, and as a fellow in Infectious Diseases at the Medical College of Pennsylvania. He joined the Wayne State University School of Medicine as a professor of internal medicine in 1985, and was named chief of the Division of Infectious Diseases.

One of the world’s foremost authorities on bacterial vaginosis, Dr. Sobel is a widely published and strongly funded physician-researcher. He has been involved in basic science, translational and clinical research since the inception of his Infectious Diseases Research Fellowship in 1976 at the NIH Laboratory of Clinical Investigation. He has served as a consultant for the U.S. Centers for Disease Control and Prevention’s special committee for recommending guidelines for the treatment of sexually transmitted diseases.

He also served as president of the Michigan Infectious Diseases Society from 1997 to 1999, and is a member of the Infectious Diseases Society of America, the National State President’s Committee and the Infectious Diseases Society of America, Practice Guidelines Committee.

The chair of the Division of Research in the internal medicine department, Dr. Sobel also is a professor of WSU Immunology and Microbiology, and of Obstetrics and Gynecology.

He received the Golden Apple Award for best clinical teacher in 1979 and the Medical House Staff Award for Excellence in Clinical Teaching in1984 at the Medical College of Pennsylvania. He was given the Distinguished Faculty Award from the WSU Department of Internal Medicine in 1986 and the School of Medicine’s Teaching Award in 2004. In 2008 he received the Gershenson Distinguished Faculty Award, and in 2011 was elected to the WSU Academy of Scholars.

Dr. Sobel has been consistently named a Best Doctor in America since 1998, a Top Doctor since 1995 and a Super Doctor since 2011.

 
Research shows anti-HIV medicines can cause damage to fetal hearts
In Headlines on November 19, 2014
Steven Lipshultz, M.D.

Steven Lipshultz, M.D.

A study by a Wayne State University School of Medicine and Children’s Hospital of Michigan, Detroit Medical Center, research team is shedding new light on the troubling question of whether the drugs often given to HIV-positive pregnant women can cause significant long-term heart problems for the non-HIV-infected babies they carry.

The study recently published in the journal AIDS shows that while the HIV medications have been successful in helping to prevent the transmission of the virus from mother to infant, they are associated with persistently impaired development of heart muscle and reduced heart performance in non-HIV-infected children whose mothers received the medicines years earlier.

“What our study indicates is that there’s potentially a long-term price to be paid for protecting the children of HIV-infected mothers from the virus,” said Steven Lipshultz, M.D., pediatrician-in-chief at the Children’s Hospital of Michigan and chair of pediatrics for the School of Medicine. Dr. Lipshultz is a specialist in the study of long-term toxic cardiac effects among children affected by cancer and HIV drug therapies.

“These medicines have been very effective at reducing the rate of transmission of HIV from mother to child,” added Dr. Lipshultz, the lead author of the study, “but the findings we’ve just published show clearly that further investigation of their long-term impact on the heart health of the children involved is needed.

“Thanks to the new anti-HIV medications, the rate of transmission has been lowered from 26 percent to less than 1 percent during the past few decades, and that has been a miracle of life for the children involved. Still, we don’t want to be protecting these children from one disease, only to give them another one.”

The study compared heart development and long-term heart functioning in 428 uninfected children of HIV-infected mothers to children who had not been exposed to HIV from 2007 to 2012. The results pointed to a significant association between lagging heart muscle development and impaired pumping ability in the children of the HIV-infected mothers who had received the medications.

“These findings clearly indicate the need for further study,” said Dr. Lipshultz, while pointing to one of the study’s key conclusions: “Subclinical differences in left ventricular structure and function with specific in-utero antiviral exposures indicate the need for a longitudinal study to assess long-term cardiac risk and cardiac monitoring recommendations.”

Dr. Lipshultz, a nationally recognized expert on pediatric cardiac care who 20 years ago led the effort to found the nation’s only registry of pediatric cardiomyopathy, said the study is a “compelling example of how clinical research can be effective in helping to shed light on complex problems in pediatric health care.”

The Children’s Research Center of Michigan team, located at the Children’s Hospital of Michigan, involved with this National Institutes of Health-supported multicenter study includes James Wilkinson, M.D., associate director of the center and professor of pediatrics, and research assistant Joslyn Westphal, M.P.H.

Dr. Wilkinson stressed the study “raises the question of how much do we know about the long-term safety of drugs given to children?” He is concerned that “pediatric drug studies remain particularly limited. The lack of information about the long-term safety of drugs prescribed for children is a special worry, both for drugs that may be used for decades for chronic conditions and for drugs for which short-term use may be found to harm children’s growth and development months or years later. Although these are effective medicines for children, in order to understand their safety, long-term pediatric safety studies are needed to potentially allow future options for improvement if serious safety risks are identified.”

“At the end of the day, our goal at the Children’s Hospital of Michigan is to provide the very best possible care for our patients,” Dr. Lipshultz said.  “Studies like this one are crucially important for meeting that challenge.”

The PHACS (Pediatric HIV/AIDS Cohort Study) is the largest U.S. government study of pediatric HIV and AIDS, with more than 30 centers. It is a trans-National Institutes of Health study with 10 NIH institutes and centers participating and funding PHACS. Since PHACS's inception more than a decade ago, Dr. Lipshultz has been the NIH-funded cardiology leader of PHACS, a member of its scientific leadership group, and the inaugural and only chair of the NIH PHACS Cardiovascular Task Force, the group which led this study.

Researchers find children, energy drinks a dangerous combination
In Headlines on November 17, 2014
Steven Lipshultz, M.D.

Steven Lipshultz, M.D.

More than 40 percent of reports about energy drinks to U.S. poison control centers involved children younger than 6, with some suffering serious cardiac and neurological symptoms, according to research by a Wayne State University School of Medicine physician-researcher presented Nov. 17 at the American Heart Association’s Scientific Sessions 2014 in Chicago.

This disproportionate representation of children is concerning given the number of reports of serious cardiac and neurological symptoms, said Steven Lipshultz, M.D., the study’s senior author and professor and chair of pediatrics at Wayne State University and pediatrician-in-chief at Children’s Hospital of Michigan in Detroit.

Researchers analyzed the October 2010-September 2013 records of the American Association of Poison Control Centers’ National Poison Data System, which contains information about calls from the public and health care providers to 55 poison control centers in the United States. “Exposure calls” are defined as those that involve actual or suspected contact with any substance that has been ingested, inhaled, absorbed, applied to or injected into the body, regardless of toxicity or clinical manifestation. Researchers found:

• Of the 5,156 reported cases of energy drink exposure, 40 percent were unintentional, (i.e. unforeseen or unplanned) exposures by young children.

• Moderate to major outcomes were reported in 42 percent of cases involving energy drinks that had been mixed with ethanol (alcohol) and in 19 percent of energy drinks that did not contain alcohol.

• Among cases across all age groups with major outcomes, cardiovascular effects (including abnormal heart rhythm and conduction abnormalities) were reported in 57 percent of cases, and neurologic effects (seizures, including status epilepticus) in 55 percent.

“Energy drinks have no place in pediatric diets,” Dr. Lipshultz said, “And anyone with underlying cardiac, neurologic or other significant medical conditions should check with their health care provider to make sure it’s safe to consume energy drinks.”

Energy drinks may contain pharmaceutical-grade caffeine and additional caffeine from natural sources that may cause the heart to race and blood pressure to increase. Energy drinks with multiple caffeine sources were tied to a higher rate of side effects, typically involving the nervous, digestive or cardiovascular systems.

Some energy drinks contain up to 400 milligrams of caffeine per can or bottle, compared to 100 to 150 mg in a typical cup of coffee, Dr. Lipshultz said. Caffeine poisoning can occur at levels higher than 400 mg a day in adults, above 100 mg a day in adolescents and at 2.5 mg per kilogram (2.2 pounds) of body weight in children younger than 12, he said.

Researchers don’t yet know whether compounds other than caffeine in the drinks contribute to the ill effects. Many of the added ingredients have never been tested for safety and have never been tested in combination.

In 2010, the U.S. Food and Drug Administration banned pre-packaged energy drinks that contain alcohol. Since then, calls to poison control centers about such drinks fell sharply, which supports the effectiveness of education and the combination ban. But some people might custom mix alcohol-energy brews, Dr. Lipshultz said.

Reports to poison control centers vastly underestimate the problem because many people who become ill from energy drinks don’t call the hotlines and emergency room visits are not included. “The reported data probably represent the tip of the iceberg,” Dr. Lipshultz said.

Researchers called for improved labeling of caffeine content and potential health consequences, as well as continued efforts to decrease children’s exposures to the products.

Co-authors of the study are Steven Seifert, M.D., University of New Mexico; Kristopher Arheart, Ph.D., University of Miami; Vivian Franco, M.P.H., University of Miami; Alvin Bronstein, M.D., Colorado School of Medicine; Stacy Fisher, M.D., University of Maryland; Brandon Warrick, M.D., University of New Mexico; and Sara Seifert, M.D., University of Miami.

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